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However, most of the drugs mentioned in the article (such as andrographolide, rapamycin, azathioprine, JAK inhibitors, etc.) have shown potential in mechanistic studies, but their clinical translation faces three major obstacles: ‘imprecise targeting, safety concerns, and difficulty in preventing drug resistance.’ Some drugs lack cell or tissue specificity, such as insufficient local drug concentration in the intestine, and are prone to systemic side effects

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Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases